Kool-Aid
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Similar to Spice from the world of Kessel, the illegal substance Kool-Aid - a clever mix of Kid's Organic Opiate Liquid And Intestinal Discharge (Klingon for refreshing) - is perhaps the most deadly substance in the universe.
Kool-Aid is also a gateway-substance to speed-typing.
While not poisonous (except in Jonestown), the user often experiences flashes in mild dementia and mania until his or her heart beats itself loose and falls out of the poor soul's anus.
Known to contain several of the more mundane barbiturates, as well as urine, tobacco and nutmeg, it is as harmful as it is delicious. The chief cartel which distributes this menace is headed by the Kool-Aid Man or KAM.
KAM appears to be some red, bipedal form of Hutt and much like his relatives, enjoys a hedonistic lifestyle funded by illegal narcotics. KAM also seems to be impervious to pain, smashing through solid walls and shouting "OH YEAH!" (much like Randy "Macho Man" Savage did for Slim Jims)
Not to be confused with Kool Aid.
Shadow the Hedgehog loves Kool-Aid and would've killed for some as he fell to earth after blowing up the Biolizard's fucking head off.