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For those without comedic tastes, the self-proclaimed experts at Wikipedia have an article about Despair.

The deepest human emotion, characteristically inscribed on the foreheads of those who worship the Beast, or Satan. It is an incurable shade of blue, like two shades of biro blended together with the tears of marmosets. It is not legally available to buy or hire, thus the black market trade in despair is booming; mainly via the metaphysical section on eBay.